Several factors contributed to the consolidation of the Cuyabeno Wildlife Reserve in Ecuador. One of them was the empowerment of indigenous organizations to establish “Use and Management Agreements” with the State. Besides that, the government defined policies for the conservation of protected areas, such as the Socio Bosque Program, the National Environment Fund, and investments in sustainable tourism. Finally, the availability of funds and technical assistance from international cooperation was key to support an initiative integration across borders (Colombia–Ecuador–Peru).