The International Centre Agricultural Research in the Dry Areas’ (ICARDA) high yielding wheat varieties with resistance to extreme heat, drought and salinity and insect pests and diseases have been adopted throughout the Central and West Asia and North Africa (CWANA) and Sub-Saharan Africa (SSA) regions, both highly vulnerable to climate change. It aimed at achieving a widespread adoption and transformative impact in terms of enhancing productivity, farmers’ income, job creation, and value addition all leading towards attaining higher levels of wheat self-sufficiency.