The global pandemic has shown societies’ vulnerability to highly infectious diseases due to Antimicrobial Resistance (AMR). It has revealed critical weaknesses in primary Health Care Facilities (HCFs), such as inadequate infection prevention and control, lack of proper waste management or infrastructural deficits. Improper excreta disposal and medical waste management are linked to the spread of vectors, vermin, and other germs. They have been associated with spreading pharmaceutical residues that contribute to increased AMR. This is the point of departure of Sanitation for Millions towards applying One Health through a WASH in HCFs approach. The project has designed a framework for its interventions based on GIZ knowledge, experience in partner countries, the Joint Monitoring Programme of WHO/UNICEF, and national policies. It is based on capacity building, promoting hygiene management, creating awareness, and designing an enabling environment that targets the reducing health risks and protecting human health.