Pathfinding elephants are moving through human-dominated landscapes, often across international boundaries. By doing so, they play a vital role in connecting Protected Areas (PAs) but also encounter Human-Elephant Conflict (HEC) that threatens lives and livelihoods. Our solution proposes a long-term strategy to conserve elephant corridors whilst incorporating the socio-economic needs of the people that share the landscape with them. GPS tracking of elephants across two transfrontier conservation areas flags where linking corridors exist and thus where to focus resources. We use innovative cafeteria-style experiments to understand which elephant-unpalatable plants would offer lucrative alternative income streams to farmers living in those HEC hotspots. Lastly, we combine food security and people’s safety by deploying Rapid Response Units and soft barriers to protect subsistence crops. This phased strategy enables the protection of bioregions to achieve biodiversity objectives at landscape scale.