The Wildlife Health Surveillance Network, known as WildHealthNet, is a regional initiative supporting national governments in Cambodia, Lao PDR, and Viet Nam to build and implement national wildlife health surveillance strategies. The project has enhanced the ability of these nations to safely detect, monitor, trace, and report emerging pathogens in wildlife, to facilitate more rapid response and mitigation. The system has already detected trans-national disease outbreaks of zoonotic diseases and pathogens of economic, wildlife, and human health significance. More rapid identification of wildlife pathogens benefits public health, livestock health, rural livelihoods and food security, and conservation.