This report is the first comprehensive attempt to collate all the relevant information on institutional arrangements for nature conservation in the region into one coherent report. It aims to review the health of the national nature conservation systems, their suitability for purpose, the main gaps and opportunities in delivering on the many national and international policy targets, and their coherency with respect to addressing regional commonalities and priorities. Despite the national specificities, the countries in South-Eastern Europe have much in common when it comes to environmental challenges and sustainable development goals. Enabling the countries to embrace this approach and effectively manage ecosystems in a transboundary and regional context, and to create shared policy, planning, and management frameworks, is a precondition and key for the region’s sustainable future.