The One Health for Humans Animals Environment and Livelihood (HEAL) project adopts a bottom-up, context-specific, evidence-based, transdisciplinary approach to increase the accessibility to human and animal health services and enhance the management of natural resources in pastoralist areas of East Africa. In this region, nomadic pastoralists are among the most vulnerable and hard-to-reach communities, often excluded from the provision of essential social and health services. The project reshapes service delivery in the form of One Health Units (OHU). By nurturing collaboration, coordination and communication between service providers working in human, animal, environmental and rangeland health, the OHU provides integrated services to the pastoralists and their livestock and supports communities to sustainably manage the rangelands they rely on. The OHU is jointly managed by the pastoralist communities, through Multi-Stakeholder Innovative Platforms (MSIP) and the local authorities, through the One Health Task Force (OHTF).